Cholesterol can be both good and bad, so it's important to learn what cholesterol is, how it affects your health and how to manage your blood cholesterol levels.

Why is LDL cholesterol considered "bad"?
When too much LDL cholesterol circulates in the blood, it can slowly build up in the walls of the arteries that feed the heart and brain. Together with other substances it can form plaque, a thick, hard deposit that can clog those arteries. This condition is known as atherosclerosis. If a clot forms and blocks a narrowed artery, it can cause a heart attack or stroke. The levels of HDL cholesterol and LDL cholesterol in the blood are measured to evaluate the risk of having a heart attack. LDL cholesterol of less than 100 mg/dL is the optimal level. Less than 130 mg/dL is near optimal for most people. A high LDL level (more than 160 mg/dL or 130 mg/dL or above if you have two or more risk factors for cardiovascular disease) reflects an increased risk of heart disease. That's why LDL cholesterol is often called "bad" cholesterol.

Why is HDL cholesterol considered "good"?
About one-third to one-fourth of blood cholesterol is carried by high-density lipoprotein (HDL). HDL cholesterol is known as the "good" cholesterol because a high level of it seems to protect against heart attack. (Low HDL cholesterol levels [less than 40 mg/dL] increase the risk for heart disease.) Medical experts think that HDL tends to carry cholesterol away from the arteries and back to the liver, where it's passed from the body. Some experts believe that HDL removes excess cholesterol from plaque in arteries, thus slowing the build-up.

What is Lp(a) cholesterol?
Lp(a) is a genetic variation of plasma LDL. A high level of Lp(a) is an important risk factor for developing fatty deposits in arteries prematurely. The way an increased Lp(a) contributes to disease isn’t understood. The lesions in artery walls contain substances that may interact with Lp(a), leading to the buildup of fatty deposits.

The triglyceride connection
Triglyceride is a form of fat. It comes from food and is also made in your body. People with high triglycerides often have a high total cholesterol, a high LDL cholesterol and a low HDL cholesterol level. Many people with heart disease also have high triglyceride levels. Triglyceride levels of less than 150 mg/dL are normal; levels from 150-199 are borderline high. Levels that are borderline high or high (200 mg/dL and above) may need treatment in some people. Doctors need to treat high triglycerides in people who also have high LDL cholesterol levels. People with diabetes or who are obese are also likely to have high triglycerides.

Coenzyme Q10 is used by cells to produce energy needed for cell growth and maintenance. It is also used by the body as an antioxidant.

Marine Omega contains ultra-pure omega-3 fatty acids to promote wellness and longevity. It combines the highest grade fish oils with oil from krill harvested from the pristine waters of Antarctica. Krill oil is rich in EPA and DHA in a unique phospholipid form targeted for use in the brain and in cell membranes throughout the body.

Update March 2007 15 years of clinical research for people with high cholesterol

Lipidol is the result of 12 years of clinical research and it has been shown to be both safe and effective for promoting heart health.
Cholestin with Lipidol works by helping to maintain existing normal cholesterol production in the liver, rather than blocking its absorption.

What is Cholestin with Lipidol? Cholestin with Lipidol contains a proprietary formula including polymethoxylated flavonoids from citrus fruit, palm fruit extract, lemongrass, EPA and DHA to create an all natural product that targets multiple steps in the pathway of cholesterol and lipoprotein synthesis. The efficacy and safety of citrus polymethoxylated flavonoids, palm fruit extract and lemongrass are supported by over 30 studies, and the cardio-friendly effects of EPA and DHA are supported by literally thousands.

What are the health benefits of Cholestin with Lipidol?
Cardiovascular health includes among other factors:
1) desirable-levels of lipoprotein structural components (such as apo B, an LDL precursor, triglycerides, and cholesterol itself)
2) antioxidant protection against LDL-oxidation
3) proper balance of anti-inflammatory response
Each ingredient in Cholestin targets one or more of the above factors.

Polymethoxylated Flavonoids - Preclinical studies have shown that the specific citrus polymethoxylated flavonoids found in Cholestin, tangeretin and nobiletin inhibited the secretion of apo B, an LDL-C precursor, from HepG2 cells (Kurowska, 2004a; 2002). A separate study showed that tangeretin inhibits apoB production by suppressing diacylglycerol actyltransferase, the final enzyme in the pathway of triglyceride synthesis, where the latter plays an important role in apoB formation (Staack, 2005). In liver cells, tangeretin rapidly reduced apoB secretion (82% reduction); it also decreased intracellular synthesis of cholesteryl esters (45% reduction), free cholesterol (64% reduction), and triacylglycerols (37% reduction). This suppression of TAG synthesis and mass were associated with decreased diacylglycerol (DAG) aceyltransferase and microsomal triglyceride transfer protein (MTP) activities (Kurowska, 2004b).

In addition to its ability to reduce plasma cholesterol concentrations, nobiletin was shown in vitro to inhibit macrophage foam cell formation (Whitman, 2005).

Tocotrienols - A number of clinical studies using tocotrienols derived from palm fruit or rice bran have been performed. Subjects receiving tocotrienol supplementation for 4-8 weeks experienced significant drops in total cholesterol of 15-20%, with the major reduction being in LDL-C, whereas HDL-C remained essentially unchanged. In a trial with pure gamma tocotrienol, similar reductions were also observed (Theriault, 1999).

Geraniol - Geraniol has been shown to exhibit potent HMG-CoA reductase activity in vitro,
more powerful than the hypolipidemic drug mevacor.
These results indicate that geraniol primarily suppresses HMG-CoA reductase synthesis at a post-transcriptional level by attenuating HMG-CoA reductase mRNA translational efficiency. (Peffley, 2003).

References

DHA and EPA - Haglund O, et al. The effect of fish oil on triglycerides, cholesterol, fibrinogen and malondialdehyde in humans supplemented with vitamin E. J Nutr 1991;121:165-169.

Haglund O, et al. Effects of fish oil on triglycerides, cholesterol, lipoprotein(a), atherogenic index and fibrinogen. Influence of degree of purification of the oil. Nutrition Research 1992;12:455-468.

April 11, 2002 issue of the New England Journal of Medicine (NEJM) indicates that omega-3’s (DHA & EPA) can lower triglyceride levels.

Phillipson BE, et al. Reduction of Plasma Lipids, Lipoproteins, and Apoproteins by Dietary Fish Oils in Patients With Hypertriglyceridemia. N Engl J Med 1985; 312(19):1210-16.

What makes Lipidol unique? Cholestin with Lipidol targets multiple steps in the pathway of cholesterol production, protects against LDL oxidation, supports normal healthy platelet adhesion and aggregation, as well as normal healthy prostaglandin activity.

We do not feel that there would be any contraindication taking Cholestin with Lipidol and Statin drugs together. However, because we are not your personal doctor, we would recommend consulting your doctor before combining natural supplements with any drug treatment.

The cheapest way to buy Cholestin is to buy directly from the pharmaceutical company website.
Here is a direct safe link: Click here